Pathological Yawing
Enviado por MelinaGardom • 10 de Marzo de 2013 • 1.692 Palabras (7 Páginas) • 247 Visitas
Yawning is a very common and phylogenetically ancient
behavioural event that occurs in vertebrates under
different conditions. A yawn consists of a stereotyped
behavioural pattern that begins with an inspiration associated
with marked dilatation of the pharynx. At the peak of
inspiration there are associated facial movements and the
final part of yawning is passive rapid expiration. During
yawning a coordinated sequence of events takes place
involving facial, oropharyngeal, tongue, and respiratory
muscles, associated with activity in the axial extensor and
limb extensor muscles and with autonomic changes characterised
by an increased parasympathetic outflow.1 The
physiological stimuli that give rise to the yawning response
and its functional significance are not clear. It has been
shown that yawning frequency is not modified by hypercapnia
or by pure oxygen breathing; it does not seem, therefore,
to have a straightforward respiratory function.2 Yawning
occurs preferentially in conditions of low vigilance and causes
transient increases in arousal as indicated by EEG desynchronisation,
though an active role in the maintenance of
arousal has not been demonstrated. The social importance of
yawning is particularly evident in mammals, where it seems
to have a communicative role in conditions of decreased
vigilance.2 The neural structures that control yawning are
presumably located in the brain stem near to or within other
respiratory and vasomotor centres, especially those that
control facial mimicry, mastication, throat movements,
respiration, and possibly stretching.3 Excessive or pathological
yawning is defined as a compulsive, repetitive action that
is not triggered by appropriate stimuli such as fatigue or
boredom. We describe here two cases of excessive yawning
behaviour associated with ischaemic lesions in the brain
stem.
CASE REPORTS
Patient 1
A 74 year old man was admitted to our clinic complaining of
unsteadiness of stance and gait, lasting for 12 hours. The
patient described an acute onset of excessive, repetitive,
compulsive yawning that he was unable to control; the
yawns were repeated at a frequency of about 3/minute. Forty
minutes later the patient also noticed gait ataxia and inability
to stand without assistance. When admitted to the hospital,
neurological examination showed a slight intention tremor of
the left arm and slight dysmetria in the finger–nose
manoeuvre; no limb weakness was present and tendon
reflexes were normal. The patient was able to stand and walk
but gait was possible only with broad based, irregular steps
and leftward veering. The cranial nerves were unaffected and
nystagmus was not present. His state of vigilance remained
normal. He reported abnormally frequent yawning for three
days following the acute onset, with progressively longer
intervals between one yawning act and the next. Three days
later, neurological examination was normal and all symptoms
had disappeared.
Magnetic resonance imaging (MRI), done three days after
the onset of the neurological deficit, showed a small
hyperintense lesion in the left paramedian region of the
middle pons on fluid attenuated inversion recovery (FLAIR)
images (fig 1, left panel). The lesion was also evident as an
area of hyperintense signal in T2 weighted images. At a three
months follow up the patient was free of all symptoms.
Patient 2
A 66 year old woman presented with the acute onset of
imbalance of stance and gait, followed two hours later by a
single episode of vomiting and by weakness of the left upper
limb. She reported an episode of unjustified excessive
yawning, at a frequency of approximately one event every
two minutes, which began 20 to 30 minutes before the
neurological symptoms. On admission to hospital, clinical
examination showed a slight left lower facial paresis,
horizontal nystagmus beating leftwards, and a right sided
internuclear ophthalmoplegia. A pronator drift in antigravity
posture and clumsiness in distal finger movements were
observed in the left upper limb. Slight proximal weakness was
present in the left lower limb as well. Tendon reflexes were
normally elicitable in the four limbs. An extensor plantar
response was present on the left side. Finger–nose and
reaching manoeuvres showed slight dysmetria on the right
and could not be evaluated on the left because of the motor
deficit. No sensory deficit could be observed in the trigeminal
or the somatic territory. The patient had a broad based gait and
a marked left lateropulsion on standing. Vigilance was normal.
MRI done five days after the onset of symptoms showed right
pontine ischaemia (fig 1, right panel) and MRI-angiography
showed a pseudo-occlusive stenosis of the basilar artery. The
frequency of yawning gradually decreased and returned to
normal within 36 hours. The motor deficit on the left side and
the gait ataxia was still present, though moderately improved,
at three weeks after symptom onset.
DISCUSSION
We describe here, for the first time, patients with brain stem
ischaemic stroke presenting with excessive yawning. The
possible causal relation between the brain stem lesion and
Abbreviation: FLAIR, fluid attenuated inversion recovery
See Editorial Commentary, p 3
98
www.jnnp.com
the excessive yawning behaviour could provide useful
information on the anatomical location of the neural systems
controlling yawning in humans.
The central anatomical pathways subserving yawning have
not been clearly defined.4 The published evidence indicates
the presence in mammals of a subcortical circuit mediating
the yawning phenomenon, involving the hypothalamus, the
midbrain, and the reticular formation of the pons and
medulla.2–4 In the rat experimentally induced excessive
yawning behaviour can be produced by direct or indirect
activation of the oxytocinergic neurones in the paraventricular
hypothalamic nucleus, which is thought to play a
primary role in initiating the yawning phenomenon. The
activity of hypothalamic yawning related neurones is subject
...