Sexo Seguro

Esquema de MICROBIOMA. Lo que voy a exponer en español sacar traducción.

1.Introducir concepto de microbioma, el mas destacado el intestinal.

It has been estimated that up to 100 trillion microbial cells make a home out of us1, and likely outnumber human body cells by an order of magnitude2, leading some to term the human microbiome our “second genome.”

2.Función: estudios con los que se ha relacionado

inmunologica

obesidad y nutricion

comportamiento

¿Depresion ¿autismo

3.Como se obtiene y sus diferencias. (factores que lo modifican y la diversidad)

modo de nacimiento. Antibioticoterapia. Dietas. síndromes de mala absorción

4.Estudios en ratones (referencias que comprueban su asociación) desarrollo neural.

Brain-gut microbioma axis

The gut and nervous systems communicate via neural mechanisms (e.g., parasympathetic innervation by the vagus nerve, as well as sympathetic innervation from multiple levels of the sympathetic chain; reviewed by 74), and endocrine pathways such as the hypothalamic-pituitary-adrenal (HPA) axis 75. In addition, immune- mediated mechanisms play important roles in the way the gut and brain influence each other’s function and development 76. GI microbes thus influence brain function and behavior through several sets of complex pathways.

Existe momento critico para el desarrollo neuronal?

Diaz Heijtz and colleagues 77 showed that GF mice emitted more locomotor behavior and rearing in an open field, as well as greater amounts of time spent in the lighted portion of a light-dark paradigm, or the open arms of an elevated plus maze, as compared to SPF mice of the same outbred strain, which the authors interpreted as reduced “anxiety-like” behavior in the GF mice. Remarkably, the authors also showed that GF mice colonized at 3 weeks of age with SPF microbiota later showed identical behaviors to SPF mice as adults, but such colonization at 6 weeks did not restore SPF-like behavior in adulthood, suggesting the hypothesis that there are critical periods during which commensal flora influence neurobehavioral development.

5.Usos terapeuticos: Mas frecuente. Mas estudiado.

6.Conclusiones

7.Referencias

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